Dose reduction of the new generation biologics (IL17 and IL23 inhibitors) in psoriasis: a pragmatic, multicentre, randomized, controlled, non-inferiority study – BeNeBio study
Welcome to the website of the BeNeBio study.
The BeNeBio study
BeNeBio is a clinical study about dose reduction of biologics for psoriasis patients.
Psoriasis is an inflammatory disease in which red, scaly patches are visible on the skin. In a substantial part of patients, the joints are also inflamed. When the disease is extensive, some patients are eligible for treatment with biologics. Biologics are drugs that are usually given to patients via injections.
The newest biologics are the so-called interleukin (IL) 17 and 23 inhibitors. These agents are usually prescribed in a fixed, standard dose. Not all patients might need this standard dose. Our aim is to investigate if the dose can be reduced in patients with stable psoriasis who are using the normal, standard dose. It is important that the disease does not worsen due to dose reduction. A lower dose has advantages: it might lead to less side effects and it might lower the healthcare costs. With this study, we want to achieve that a part of the patients can be treated with less medication, while the effect on the skin remains positive.
For more information regarding the study, click here.
Collaboration Belgium and the Netherlands
The BeNeBio study is a collaboration between the departments of dermatology of the Radboudumc (Netherlands) and Ghent University Hospital (Belgium). The study is funded by ZonMw and KCE through a joint project. By collaborating, more research data can be collected. This might lead to better results.
Psoriasis (vulgaris) is an inflammatory disease in which red, scaly patches are visible on the skin. These patches are itchy and sometimes painful. Psoriasis patches can range from a few spots to large patches across the whole body. Commonly affected areas are the elbows, knees, legs, and scalp. In a substantial part of patients, the joints are also inflamed. Psoriasis is thought to be an immune mediated disease in which many factors play a role, such as genetics and environmental factors. The condition is not contagious. Many treatments for psoriasis target the immune system, such as hormone ointments and biologics. Unfortunately, there is no definitive cure for psoriasis.